Like where the bad guys are?
If it's daylight, I wouldn't worry about walking north of Sunset in those areas, though it gets a little, as the young people call it, "sketch," on Sunset east of Silver Lake, heading into Echo Park...but not like down at USC, or anything, lol.
From my place just a few blocks west and north of Franklin Village, I've walked/wheeled to Hillhurst, to Cahuenga and Yucca, to Hollywood and Highland. When ever peeps from out of town visit, I walk them around the touristy stuff on the Blvd and take em to Roscoes on Gower, and that's at night. We stumbled down to Sunset and Vine after my birthday bbq last summer and stumbled back after last call (good times), I walk to the Arclight for day screenings.
You can totally walk here! For exercise I have a route up into the hills, past the Hollywood sign and then down into Beachwood Canyon, then back up to my place, I've done it night and day.
Oh, and or some reason, Argyle's 101 overpass seems less overpass-creepy to me than the Gower one, if you're heading to or from Franklin.
Have fun, and good luck!